Regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP4C, STK11IP, and SLA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP4C grouped by Regulation of proteasomal ubiquitin-dependent protein catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPP4C →	-0.434	-0.101	<.001	<.001	3	6
PANCREAS	STK11IP →	+0.179	+0.157	.009	.002	3	5
LIVER	SLA2 →	+0.334	+0.303	<.001	.001	3	5
STOMACH	TAF1 →	-0.542	-0.127	.002	.006	3	5
CNS	MSANTD3-TMEFF1 →	+0.159	+0.198	.002	.006	3	5
SKIN	MDM2 →	-0.536	-0.117	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP4C by Regulation of proteasomal ubiquitin-dependent protein catabolic process activity — SKIN

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