Regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC25B, CEP55, and SESN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC25B grouped by Regulation of proteasomal ubiquitin-dependent protein catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CDC25B →	-1.051	-0.203	<.001	.004	3	5
PANCREAS	CEP55 →	-0.832	-0.112	.003	.003	3	5
LARGE_INTESTINE	SESN1 →	+1.092	+0.149	.009	<.001	3	5
OVARY	CCT4 →	-0.545	-0.178	.001	<.001	3	5
BREAST	RSAD1 →	+1.006	+0.152	<.001	<.001	3	5
BREAST	LRRC75B →	+2.021	+0.172	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC25B by Regulation of proteasomal ubiquitin-dependent protein catabolic process activity — LIVER

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