Regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL28, DCAF5, and GPATCH2L, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus KLHL28 in STOMACH (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KLHL28 →	+0.833	+0.063	<.001	<.001	3	18
KIDNEY	DCAF5 →	+1.149	+0.065	<.001	<.001	3	18
BLOOD_Lymphoma	GPATCH2L →	+1.157	+0.067	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	ARIH1 →	+0.934	+0.070	.003	.002	3	16
LARGE_INTESTINE	ATXN1L →	+0.931	+0.065	<.001	<.001	3	16
OESOPHAGUS	VPS9D1 →	+1.186	+0.078	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032434 vs KLHL28 — STOMACH

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