Regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAIP1, PACSIN3, and DNAAF5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus MAIP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MAIP1 →	+0.854	+0.303	.003	.002	2	8
OVARY	PACSIN3 →	+1.025	+0.146	.001	.002	3	7
LIVER	DNAAF5 →	+1.552	+0.290	.005	<.001	3	6
BLOOD_Myeloma	TRAP1 →	+1.163	+0.238	.001	.001	2	7
BREAST	PSMD14 →	+0.573	+0.121	.002	.004	3	6
STOMACH	BCS1L →	+0.819	+0.264	.008	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032434 vs MAIP1 — UPPER_AERODIGESTIVE_TRACT

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