Positive regulation of sodium:proton antiporter activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of sodium:proton antiporter activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBR1, EIF3J, and TESC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sodium:proton antiporter activity activity versus UBR1 in OV (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UBR1 →	+0.178	+0.074	.005	.003	3	5
BRCA	EIF3J →	+0.179	+0.066	.006	.003	3	5
LUAD	TESC →	+1.233	+0.185	<.001	<.001	3	4
LUAD	MYO5C →	+0.292	+0.095	.009	.001	2	5
BRCA	COG3 →	+0.309	+0.072	<.001	<.001	3	4
BRCA	COG8 →	+0.212	+0.060	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032417 vs UBR1 — OV

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