Positive regulation of sodium:proton antiporter activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of sodium:proton antiporter activity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF549, ARGLU1, and PEAR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sodium:proton antiporter activity activity versus ZNF549 in CCRCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNF549 →	+0.362	+0.505	.005	<.001	3	3
BRCA	ARGLU1 →	+0.610	+0.512	<.001	.003	3	3
CCRCC	PEAR1 →	+0.531	+0.365	<.001	.001	3	3
UCEC	RNU6-1242P →	-1.070	-0.490	<.001	.001	3	3
CCRCC	REM1 →	+0.705	+0.529	.001	.001	3	3
CCRCC	ADAMTSL2 →	+1.171	+0.540	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032417 vs ZNF549 — CCRCC

Explore this scatter interactively →