Negative regulation of ion transmembrane transporter activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of ion transmembrane transporter activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX47, SHANK3, and SYNPO_S854, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ion transmembrane transporter activity activity versus DDX47 in GBM (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX47 →	-0.299	-0.037	<.001	.004	3	6
CCRCC	SHANK3 →	+0.637	+0.069	<.001	<.001	3	6
HNSC	SYNPO_S854 →	+0.357	+0.035	<.001	<.001	3	6
BRCA	SRSF9 →	-0.291	-0.020	<.001	.006	3	6
BRCA	NUP93 →	-0.158	-0.018	<.001	.003	3	6
LSCC	U2SURP_S788 →	-0.793	-0.038	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032413 vs DDX47 — GBM

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