Negative regulation of ion transmembrane transporter activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of ion transmembrane transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NASP, CEP97, and UBE3D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ion transmembrane transporter activity activity versus NASP in PANCREAS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NASP →	+0.677	+1.123	.005	.009	3	5
URINARY_TRACT	CEP97 →	+1.005	+1.876	.002	<.001	3	5
LUNG_NSCLC_LUAD	UBE3D →	+0.638	+1.093	.001	<.001	3	4
KIDNEY	TBPL1 →	+0.985	+1.640	.003	.002	2	5
UPPER_AERODIGESTIVE_TRACT	P2RX5 →	+2.290	+1.504	<.001	<.001	3	4
BLOOD_Leukemia	HASPIN →	+0.858	+0.640	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032413 vs NASP — PANCREAS

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