Negative regulation of transporter activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of transporter activity pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RASIP1_S41, AHCTF1, and RBM34, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transporter activity activity versus RASIP1_S41 in CCRCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RASIP1_S41 →	+0.627	+0.045	<.001	.001	3	6
BRCA	AHCTF1 →	-0.207	-0.021	<.001	.008	3	5
CCRCC	RBM34 →	-0.333	-0.055	<.001	<.001	3	5
GBM	SNRNP40 →	-0.199	-0.039	.001	<.001	3	5
HNSC	CDC27 →	-0.141	-0.036	.004	.003	3	5
HNSC	GTPBP4 →	-0.252	-0.039	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032410 vs RASIP1_S41 — CCRCC

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