Negative regulation of transporter activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBPL1, SLC44A5, and IK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transporter activity activity versus TBPL1 in KIDNEY (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TBPL1 →	+0.986	+1.591	.003	.002	3	5
STOMACH	SLC44A5 →	+1.614	+1.094	.001	.007	3	4
URINARY_TRACT	IK →	+0.702	+1.436	.004	.004	3	4
URINARY_TRACT	GKAP1 →	+1.862	+1.874	<.001	<.001	3	4
URINARY_TRACT	MISP →	-3.684	-1.417	<.001	.002	3	4
BLOOD_Leukemia	KLF12 →	+1.668	+0.621	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032410 vs TBPL1 — KIDNEY

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