Regulation of transporter activity

pathway activity — cross-omics
GO:0032409Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of transporter activity pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP11, KANK2, and PRPF40A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCUTP11 →-0.380-0.023<.001.00137
CCRCCKANK2 →+0.516+0.034<.001<.00137
GBMPRPF40A →-0.203-0.040<.001<.00137
OVCASKIN2_S471 →+0.870+0.014<.001.00437
OVRPL7L1 →-0.398-0.020<.001<.00137
GBMUTP15 →-0.205-0.033<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration