Positive regulation of intracellular transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of intracellular transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, FRAT2, and CEP162, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intracellular transport activity versus ANXA2 in LUNG_SCLC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA2 →	+2.222	+0.133	<.001	.002	3	7
OVARY	FRAT2 →	-1.450	-0.185	.004	.005	3	5
UPPER_AERODIGESTIVE_TRACT	CEP162 →	-0.642	-0.133	.006	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PPARGC1B →	-0.669	-0.126	<.001	<.001	3	5
STOMACH	PXN →	+1.701	+0.177	.001	.002	3	5
LARGE_INTESTINE	TMOD3 →	+0.747	+0.142	.003	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032388 vs ANXA2 — LUNG_SCLC

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