Negative regulation of intracellular transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of intracellular transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, UCHL1, and SH3RF3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intracellular transport activity versus MAP1B in UCEC (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP1B →	+1.374	+0.314	<.001	<.001	3	8
CCRCC	UCHL1 →	+2.058	+0.284	<.001	<.001	3	6
LSCC	SH3RF3 →	+0.550	+0.261	<.001	<.001	3	5
CCRCC	MAFG →	+0.457	+0.277	<.001	<.001	3	5
UCEC	DST-AS1 →	+0.452	+0.241	.001	<.001	2	6
LSCC	MAP2 →	+1.204	+0.224	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032387 vs MAP1B — UCEC

Explore this scatter interactively →