Negative regulation of intracellular transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of intracellular transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NONO, ACTR2, and COMMD9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intracellular transport activity versus NONO in SKIN (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NONO →	+0.664	+0.208	.001	.002	3	6
OESOPHAGUS	ACTR2 →	+0.812	+0.152	.004	.007	3	5
LARGE_INTESTINE	COMMD9 →	+0.670	+0.149	.002	.004	3	5
URINARY_TRACT	ASB8 →	+0.781	+0.378	.003	.003	3	5
BONE	GRP →	+6.384	+0.223	<.001	<.001	3	5
PANCREAS	NFIC →	+1.508	+0.283	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032387 vs NONO — SKIN

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