Positive regulation of sterol transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA1, FGD2, and MS4A14, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sterol transport activity versus ABCA1 in SCLC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ABCA1 →	+1.675	+0.157	<.001	<.001	3	30
LAML	FGD2 →	+1.758	+0.060	<.001	<.001	3	27
LAML	MS4A14 →	+1.670	+0.056	<.001	<.001	3	26
SCLC	DPEP2 →	+1.042	+0.120	<.001	<.001	3	26
KICH	PIK3R6 →	+1.035	+0.053	<.001	<.001	3	26
SARC	ABCA9 →	+1.500	+0.031	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032373 vs ABCA1 — SCLC

Explore this scatter interactively →