Positive regulation of sterol transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COQ8A, SHPRH, and ARHGDIB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sterol transport activity versus COQ8A in OESOPHAGUS (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	COQ8A →	-0.996	-0.276	.002	<.001	2	6
CNS	SHPRH →	-0.588	-0.228	.002	.004	3	5
LARGE_INTESTINE	ARHGDIB →	+2.580	+0.242	.001	<.001	3	5
SKIN	ZNF394 →	-0.795	-0.353	.001	.001	3	5
CNS	TAF5 →	-0.803	-0.287	<.001	.005	2	5
LIVER	ARPC5 →	+0.960	+0.412	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032373 vs COQ8A — OESOPHAGUS

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