Regulation of sterol transport

Across TCGA patient cohorts, RNA activity of the Regulation of sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTH1R, SRPX, and CENPA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sterol transport activity versus PTH1R in BRCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTH1R →	+0.582	+0.227	<.001	<.001	3	8
BRCA	SRPX →	+1.308	+0.244	<.001	<.001	3	7
UCEC	CENPA →	-0.981	-0.148	.002	<.001	3	7
BRCA	MMP19 →	+1.139	+0.231	<.001	<.001	3	7
BRCA	MAF →	+0.688	+0.216	<.001	<.001	3	7
OV	DACT3 →	+0.816	+0.177	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032371 vs PTH1R — BRCA

Explore this scatter interactively →