Regulation of sterol transport

Across TCGA cell cohorts, RNA activity of the Regulation of sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRAP1, PTRH1, and TRAPPC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DRAP1 grouped by Regulation of sterol transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DRAP1 →	-1.884	-1.338	.008	.005	2	6
CNS	PTRH1 →	-0.755	-0.749	.008	.006	2	6
CNS	TRAPPC3 →	-0.440	-0.849	<.001	<.001	3	5
CNS	MSANTD3 →	-1.207	-0.954	.001	.002	3	5
KIDNEY	TRIM22 →	-2.840	-0.940	.006	.005	2	6
LIVER	HDAC7 →	-1.317	-1.413	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DRAP1 by Regulation of sterol transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →