Regulation of sterol transport

Across TCGA cell cohorts, RNA activity of the Regulation of sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELK3, CDRT1, and SUMF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sterol transport activity versus ELK3 in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ELK3 →	+1.106	+0.201	.008	.006	3	5
OESOPHAGUS	CDRT1 →	+2.087	+0.213	.005	.003	2	6
BLOOD_Leukemia	SUMF1 →	+0.790	+0.223	<.001	<.001	3	4
BLOOD_Leukemia	CAPN2 →	+1.817	+0.191	.005	.002	3	4
OESOPHAGUS	TAF4B →	-0.684	-0.218	.001	<.001	3	4
SOFT_TISSUE	KIFAP3 →	+2.585	+0.384	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032371 vs ELK3 — BLOOD_Leukemia

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