Positive regulation of lipid transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KDM1A, RSU1, and ACTL6A_S233, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid transport activity versus KDM1A in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KDM1A →	-0.253	-0.049	<.001	<.001	3	7
COAD	RSU1 →	+0.431	+0.028	<.001	<.001	3	7
LSCC	ACTL6A_S233 →	-0.625	-0.042	<.001	<.001	3	7
BRCA	VIM →	+0.327	+0.023	<.001	<.001	3	7
GBM	RNASET2 →	+0.488	+0.063	<.001	<.001	3	7
CCRCC	FGD6_S605 →	+0.804	+0.048	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032370 vs KDM1A — LSCC

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