Positive regulation of lipid transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, MAFB, and NCF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid transport activity versus SPP1 in LUAD (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPP1 →	+1.339	+0.157	<.001	<.001	3	7
GBM	MAFB →	+1.256	+0.371	<.001	<.001	3	7
CCRCC	NCF2 →	+0.878	+0.328	<.001	<.001	3	6
GBM	ADCY7 →	+0.728	+0.325	<.001	<.001	3	6
CCRCC	ALOX5AP →	+0.809	+0.210	.001	.003	3	6
GBM	CTSB →	+1.095	+0.359	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032370 vs SPP1 — LUAD

Explore this scatter interactively →