Positive regulation of lipid transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL17A1, CCDC112, and SHLD3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid transport activity versus COL17A1 in OESOPHAGUS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	COL17A1 →	+3.400	+0.200	<.001	.005	3	7
BONE	CCDC112 →	+0.794	+0.326	.001	.004	3	4
STOMACH	SHLD3 →	-0.609	-0.216	.009	.006	3	4
SOFT_TISSUE	RPA2 →	-1.195	-0.319	.001	.004	3	4
SOFT_TISSUE	SLC66A3 →	+1.076	+0.264	.008	<.001	3	4
BLOOD_Leukemia	LUC7L →	-0.640	-0.177	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032370 vs COL17A1 — OESOPHAGUS

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