Negative regulation of lipid transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, CRYBG2, and CATSPERZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid transport activity versus IRS2 in OV (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRS2 →	+1.012	+0.174	.008	.002	2	5
PDAC	CRYBG2 →	-0.643	-0.071	<.001	.003	3	3
PDAC	CATSPERZ →	+0.044	+0.089	<.001	<.001	3	3
GBM	STYK1 →	-0.618	-0.187	<.001	<.001	3	3
CCRCC	VSIG4 →	+0.841	+0.097	.002	.005	2	4
GBM	CD163 →	+0.994	+0.172	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032369 vs IRS2 — OV

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