Negative regulation of lipid transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF606, TMEM11, and EIF4A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF606 grouped by Negative regulation of lipid transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZNF606 →	+1.273	+1.231	.001	<.001	3	3
KIDNEY	TMEM11 →	-0.547	-1.125	.006	.001	3	3
BONE	EIF4A1 →	-0.650	-1.618	.006	.001	3	3
OVARY	FAAH2 →	+1.509	+0.927	.003	.006	3	3
SOFT_TISSUE	CDYL →	+0.815	+1.153	<.001	.005	3	3
SOFT_TISSUE	SACM1L →	-0.902	-1.293	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF606 by Negative regulation of lipid transport activity — KIDNEY

Explore this box plot interactively →