Negative regulation of lipid transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipid transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS18, XKR8, and BCR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS18 grouped by Negative regulation of lipid transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPS18 →	-0.339	-0.142	<.001	<.001	3	5
LIVER	XKR8 →	-0.223	-0.175	<.001	.001	3	4
LARGE_INTESTINE	BCR →	-0.183	-0.120	.001	.003	3	4
STOMACH	COL4A4 →	+0.231	+0.180	.002	.003	3	4
BLOOD_Leukemia	ZNF415 →	-0.193	-0.087	.004	.006	3	4
LUNG_SCLC	DLEC1 →	-0.273	-0.113	.009	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS18 by Negative regulation of lipid transport activity — LUNG_SCLC

Explore this box plot interactively →