Regulation of lipid transport

Across TCGA cell cohorts, RNA activity of the Regulation of lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERINC2, CACHD1, and IGFBP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERINC2 grouped by Regulation of lipid transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SERINC2 →	-2.521	-0.990	.001	<.001	3	4
OVARY	CACHD1 →	+1.531	+0.908	.001	<.001	3	4
OVARY	IGFBP6 →	-2.970	-1.173	.003	.001	3	4
LUNG_NSCLC_LUAD	DPP4 →	-1.357	-0.470	.007	<.001	3	3
CNS	DTNB →	+0.383	+0.913	.008	.001	3	3
LIVER	SLC30A3 →	+1.536	+0.164	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERINC2 by Regulation of lipid transport activity — CNS

Explore this box plot interactively →