Regulation of lipid transport

Across TCGA cell cohorts, RNA activity of the Regulation of lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP37, MIS12, and PHIP, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid transport activity versus USP37 in LUNG_SCLC (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	USP37 →	-0.678	-0.076	.005	.003	2	12
SOFT_TISSUE	MIS12 →	-0.823	-0.084	<.001	<.001	3	11
BREAST	PHIP →	-0.755	-0.096	<.001	<.001	3	11
SOFT_TISSUE	ZNF519 →	-1.091	-0.066	<.001	.003	3	11
BLOOD_Leukemia	TRA2B →	-0.600	-0.067	<.001	<.001	3	11
LIVER	PHF6 →	-0.887	-0.076	.002	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032368 vs USP37 — LUNG_SCLC

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