Regulation of lipid transport

Across TCGA cell cohorts, RNA activity of the Regulation of lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC5, RPS4X, and VPS50, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid transport activity versus EXOSC5 in CNS (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EXOSC5 →	-0.904	-0.254	<.001	<.001	3	5
PANCREAS	RPS4X →	-1.132	-0.205	<.001	.006	3	4
LUNG_NSCLC_LUAD	VPS50 →	+0.476	+0.162	.009	.007	3	4
LUNG_NSCLC_LUSC	ARPC1A →	+1.804	+0.354	.001	.004	3	4
LUNG_NSCLC_LUSC	MAP11 →	+1.550	+0.356	.003	.004	3	4
LUNG_NSCLC_LUSC	GNB2 →	+1.081	+0.247	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032368 vs EXOSC5 — CNS

Explore this scatter interactively →