Intracellular sterol transport

Across TCGA patient cohorts, RNA activity of the Intracellular sterol transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADH1B, POLR1F, and SRP68, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular sterol transport activity versus ADH1B in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADH1B →	+1.646	+0.033	<.001	<.001	3	5
LUAD	POLR1F →	-0.279	-0.033	.001	.001	3	5
GBM	SRP68 →	-0.146	-0.043	<.001	<.001	3	5
PDAC	MAP1B →	+0.346	+0.035	.002	.001	3	5
GBM	ARFGEF3 →	+0.408	+0.056	<.001	<.001	3	5
GBM	ARHGEF1 →	-0.185	-0.038	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032366 vs ADH1B — BRCA

Explore this scatter interactively →