Intracellular sterol transport

Across TCGA patient cohorts, RNA activity of the Intracellular sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF9, RAD51AP1, and BRIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular sterol transport activity versus TNFSF9 in CCRCC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNFSF9 →	+0.680	+0.495	.002	.003	3	4
BRCA	RAD51AP1 →	-0.730	-0.245	<.001	.001	3	4
BRCA	BRIP1 →	-0.752	-0.249	<.001	<.001	3	4
LSCC	SEMA4B →	+0.677	+0.153	.006	.001	3	4
HNSC	MIXL1 →	-0.516	-0.246	.003	.003	3	3
OV	TMPO →	-0.543	-0.575	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032366 vs TNFSF9 — CCRCC

Explore this scatter interactively →