Intracellular sterol transport

Across TCGA cell cohorts, RNA activity of the Intracellular sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1A1, ASAH1, and SUSD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular sterol transport activity versus EEF1A1 in PANCREAS (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EEF1A1 →	-0.805	-0.279	.001	.005	3	6
BLOOD_Leukemia	ASAH1 →	+0.965	+0.174	.003	.001	3	5
BLOOD_Leukemia	SUSD1 →	+1.307	+0.224	.002	.005	3	5
LARGE_INTESTINE	NOP53 →	-0.631	-0.179	.004	.003	2	5
OESOPHAGUS	SNHG32 →	-1.198	-0.268	.004	.009	3	4
LUNG_SCLC	RPL31 →	-1.023	-0.239	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032366 vs EEF1A1 — PANCREAS

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