Intracellular lipid transport

Across TCGA patient cohorts, RNA activity of the Intracellular lipid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, SYT7, and RPL6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular lipid transport activity versus SEPTIN4_S432 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4_S432 →	+0.859	+0.060	<.001	<.001	3	5
GBM	SYT7 →	+1.049	+0.051	<.001	<.001	3	5
OV	RPL6 →	-0.303	-0.043	<.001	<.001	3	5
GBM	OPA1 →	+0.359	+0.061	<.001	<.001	3	5
GBM	CTDSPL2 →	-0.484	-0.052	<.001	<.001	3	4
GBM	ABCF1_S109 →	-0.273	-0.048	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032365 vs SEPTIN4_S432 — GBM

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