Intracellular lipid transport

Across TCGA patient cohorts, RNA activity of the Intracellular lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP35, SH3BGRL3, and CCDC34, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular lipid transport activity versus NUP35 in LSCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NUP35 →	-0.568	-0.175	.001	<.001	3	6
OV	SH3BGRL3 →	+0.861	+0.201	<.001	.002	3	5
BRCA	CCDC34 →	-0.635	-0.150	.001	.003	3	4
GBM	CDK2 →	-0.478	-0.213	.001	.001	3	4
GBM	KNTC1 →	-0.595	-0.182	.001	.003	3	4
HNSC	CHST10 →	-0.786	-0.179	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032365 vs NUP35 — LSCC

Explore this scatter interactively →