Intracellular lipid transport

Across TCGA cell cohorts, RNA activity of the Intracellular lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS2, RPL18A, and RPL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular lipid transport activity versus RPS2 in LUNG_SCLC (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPS2 →	-0.953	-0.283	<.001	.001	3	7
BREAST	RPL18A →	-0.804	-0.172	<.001	<.001	3	7
LUNG_SCLC	RPL3 →	-0.619	-0.319	.006	<.001	3	6
PANCREAS	RPL34 →	-0.587	-0.221	.006	.009	3	6
LARGE_INTESTINE	EEF1A1 →	-0.682	-0.267	.003	.002	2	7
BLOOD_Leukemia	WDCP →	-0.619	-0.176	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032365 vs RPS2 — LUNG_SCLC

Explore this scatter interactively →