Response to estradiol

Across TCGA cell cohorts, RNA activity of the Response to estradiol pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAAT4, ELFN2, and AFAP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to estradiol activity versus PLAAT4 in PANCREAS (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PLAAT4 →	+2.687	+0.034	<.001	.007	3	10
LUNG_NSCLC_LUAD	ELFN2 →	+1.135	+0.051	<.001	<.001	3	10
SKIN	AFAP1 →	+1.620	+0.071	<.001	<.001	3	10
CNS	NIBAN2 →	+2.058	+0.053	<.001	<.001	3	9
BLOOD_Lymphoma	RALB →	+1.726	+0.061	<.001	<.001	3	9
LIVER	PLK2 →	+3.211	+0.085	.007	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032355 vs PLAAT4 — PANCREAS

Explore this scatter interactively →