Response to estradiol

Across TCGA cell cohorts, RNA activity of the Response to estradiol pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD2A, RHOC, and RMND1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to estradiol activity versus MFSD2A in LUNG_SCLC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MFSD2A →	+2.760	+0.223	.003	<.001	2	6
BLOOD_Lymphoma	RHOC →	-2.560	-0.157	.001	.005	3	5
BREAST	RMND1 →	-1.308	-0.270	.002	.001	3	5
PANCREAS	BLOC1S6 →	-0.825	-0.234	<.001	.005	3	5
BLOOD_Leukemia	ZNHIT6 →	-0.570	-0.229	.001	<.001	3	5
PANCREAS	LATS1 →	-0.524	-0.162	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032355 vs MFSD2A — LUNG_SCLC

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