Response to follicle-stimulating hormone

Across TCGA patient cohorts, RNA activity of the Response to follicle-stimulating hormone pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1S, VCL_S795, and C1R, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to follicle-stimulating hormone activity versus C1S in OV (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1S →	+0.608	+0.080	<.001	<.001	3	10
LSCC	VCL_S795 →	+0.579	+0.071	<.001	<.001	3	9
OV	C1R →	+0.616	+0.075	<.001	<.001	3	9
CCRCC	CLEC3B →	+0.760	+0.080	<.001	.001	3	8
GBM	COL6A3 →	+1.178	+0.115	<.001	<.001	3	8
GBM	SERPING1 →	+0.571	+0.078	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032354 vs C1S — OV

Explore this scatter interactively →