Response to follicle-stimulating hormone

Across TCGA patient cohorts, RNA activity of the Response to follicle-stimulating hormone pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JCAD_S755, KANK2_S540, and NKAP_S149, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to follicle-stimulating hormone activity versus JCAD_S755 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JCAD_S755 →	+0.761	+0.768	<.001	<.001	3	3
GBM	KANK2_S540 →	+0.558	+0.804	<.001	.001	3	3
BRCA	NKAP_S149 →	-0.777	-0.487	<.001	<.001	3	3
OV	RTN4_S181 →	+0.808	+0.612	.001	.001	3	3
OV	BCHE →	+0.549	+0.522	<.001	<.001	3	3
OV	WEE1_S139 →	-0.857	-0.465	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032354 vs JCAD_S755 — UCEC

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