Response to follicle-stimulating hormone

Across TCGA cell cohorts, RNA activity of the Response to follicle-stimulating hormone pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUV39H1, TIAM1, and SLC22A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUV39H1 grouped by Response to follicle-stimulating hormone-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SUV39H1 →	+0.780	+1.392	.002	<.001	3	4
BLOOD_Myeloma	TIAM1 →	+1.892	+1.384	.003	.003	3	4
KIDNEY	SLC22A4 →	-1.487	-1.283	.003	<.001	3	4
BREAST	ELL2 →	+1.309	+0.857	.005	.001	3	3
BREAST	ERAP1 →	+0.976	+0.655	.004	.007	3	3
BREAST	FAXDC2 →	+1.048	+1.144	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUV39H1 by Response to follicle-stimulating hormone activity — SOFT_TISSUE

Explore this box plot interactively →