Negative regulation of hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of hormone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMELESS_S1173, NFKB1, and LMCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hormone biosynthetic process activity versus TIMELESS_S1173 in LSCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TIMELESS_S1173 →	-0.881	-0.069	<.001	<.001	3	5
LSCC	NFKB1 →	+0.188	+0.046	<.001	.001	3	5
PDAC	LMCD1 →	+0.374	+0.063	<.001	.001	3	5
GBM	RIF1 →	-0.367	-0.090	.002	.005	3	4
GBM	SETD2_T1853 →	-0.522	-0.105	<.001	<.001	3	4
GBM	TNS1_S1505 →	+0.566	+0.114	.006	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032353 vs TIMELESS_S1173 — LSCC

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