Negative regulation of hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFITM1, NR1D2, and MSANTD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFITM1 grouped by Negative regulation of hormone biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFITM1 →	-4.162	-1.102	.002	.009	3	4
BONE	NR1D2 →	+2.010	+1.549	.008	<.001	3	4
LUNG_NSCLC_LUAD	MSANTD3 →	+0.853	+0.603	<.001	.008	3	4
SKIN	PLEKHG3 →	+0.912	+1.131	.005	<.001	3	3
SKIN	TUT4 →	+0.395	+1.136	<.001	<.001	3	3
SKIN	NUDT11 →	-1.305	-0.952	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFITM1 by Negative regulation of hormone biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →