Positive regulation of hormone metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of hormone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RDH10, BICD2_S823, and IGFBP3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hormone metabolic process activity versus RDH10 in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RDH10 →	+0.769	+0.061	<.001	.003	3	7
PDAC	BICD2_S823 →	+0.288	+0.044	<.001	<.001	3	5
PDAC	IGFBP3 →	+0.596	+0.060	.001	<.001	3	5
GBM	LAMB1 →	+0.530	+0.072	.001	.006	3	5
UCEC	MTA2 →	-0.248	-0.066	.002	.006	3	5
PDAC	JMJD1C_S943 →	-0.513	-0.034	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032352 vs RDH10 — OV

Explore this scatter interactively →