Positive regulation of hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGR1, RDH10, and FOS, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hormone metabolic process activity versus EGR1 in BLOOD_Myeloma (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EGR1 →	+2.981	+0.137	<.001	<.001	3	17
SOFT_TISSUE	RDH10 →	+2.647	+0.206	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	FOS →	+2.898	+0.204	.001	<.001	3	13
OVARY	ARNT →	+0.956	+0.221	<.001	<.001	3	11
CNS	ZFP36 →	+1.346	+0.135	<.001	<.001	3	10
STOMACH	FOSB →	+3.253	+0.236	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032352 vs EGR1 — BLOOD_Myeloma

Explore this scatter interactively →