Positive regulation of hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF713, ABHD4, and STEAP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hormone metabolic process activity versus ZNF713 in BLOOD_Lymphoma (Pearson r = -0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF713 →	-0.539	-1.456	.007	<.001	3	5
LIVER	ABHD4 →	+1.843	+0.329	.005	.002	3	4
LIVER	STEAP3 →	+1.962	+0.329	.004	.002	3	4
SKIN	CPSF4 →	+0.630	+0.630	.003	.009	3	4
BLOOD_Lymphoma	ATXN1 →	+3.603	+1.456	<.001	<.001	3	4
BLOOD_Leukemia	POR →	+0.776	+1.050	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032352 vs ZNF713 — BLOOD_Lymphoma

Explore this scatter interactively →