Negative regulation of hormone metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-343P, FAM157B, and TBL1XR1-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hormone metabolic process activity versus RNU6-343P in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-343P →	-0.513	-0.556	.002	<.001	3	4
LSCC	FAM157B →	+0.493	+0.601	.001	.006	3	4
GBM	TBL1XR1-AS1 →	-0.394	-0.410	.007	.004	3	3
COAD	PTTG4P →	-0.251	-0.517	.009	<.001	3	3
COAD	FABP5P9 →	-0.538	-0.668	<.001	<.001	3	3
LUAD	RN7SL508P →	-0.448	-0.480	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032351 vs RNU6-343P — COAD

Explore this scatter interactively →