Negative regulation of hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K4, TNS3, and LUZP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP4K4 grouped by Negative regulation of hormone metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAP4K4 →	+1.003	+0.790	.001	.002	2	5
CNS	TNS3 →	+1.603	+0.446	.003	.003	3	4
BLOOD_Leukemia	LUZP1 →	+1.079	+1.292	.002	.001	3	4
LUNG_NSCLC_LUAD	LRFN4 →	+1.258	+0.975	.008	.001	3	4
BREAST	PLEKHA3 →	+0.722	+0.720	.004	.006	3	4
BLOOD_Leukemia	C3orf35 →	-0.252	-0.791	.008	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP4K4 by Negative regulation of hormone metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →