Negative regulation of hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of hormone metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF524, PSMD1, and RNF186, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF524 grouped by Negative regulation of hormone metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF524 →	+0.139	+0.189	.002	<.001	2	1
CNS	PSMD1 →	-0.209	-0.189	.001	<.001	2	1
CNS	RNF186 →	-0.145	-0.189	.001	<.001	2	1
CNS	ASMT →	+0.260	+0.189	.005	<.001	2	1
CNS	TAF2 →	+0.840	+0.189	.005	<.001	2	1
CNS	ANKEF1 →	+0.229	+0.189	.004	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF524 by Negative regulation of hormone metabolic process activity — CNS

Explore this box plot interactively →