Regulation of hormone metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFAT5, NBEAL1, and PITRM1-AS1, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hormone metabolic process activity versus NFAT5 in THYM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	NFAT5 →	+1.425	+0.037	.001	<.001	3	21
KIRP	NBEAL1 →	+0.585	+0.027	<.001	<.001	3	21
KIRC	PITRM1-AS1 →	+0.336	+0.031	<.001	<.001	3	21
UCEC	RDH10-AS1 →	+0.368	+0.016	<.001	<.001	3	21
KIRP	RPL37P12 →	+0.585	+0.031	<.001	<.001	3	21
DLBC	PCNX1 →	+1.057	+0.043	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032350 vs NFAT5 — THYM

Explore this scatter interactively →