Regulation of hormone metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of hormone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SON_T959, FANCD2_S1435, and MKI67_S2528, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hormone metabolic process activity versus SON_T959 in BRCA (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SON_T959 →	-0.365	-0.024	<.001	<.001	3	5
CCRCC	FANCD2_S1435 →	-0.721	-0.059	.001	<.001	3	5
CCRCC	MKI67_S2528 →	-0.717	-0.041	.001	<.001	3	5
OV	RDH10 →	+0.584	+0.037	<.001	.002	3	5
LUAD	BRIP1_S128 →	-0.805	-0.038	<.001	.004	3	5
GBM	FGF2 →	+0.459	+0.045	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032350 vs SON_T959 — BRCA

Explore this scatter interactively →