Regulation of hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS34, SPEG, and CHST14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hormone metabolic process activity versus MRPS34 in STOMACH (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MRPS34 →	+0.831	+0.342	<.001	.001	3	4
BLOOD_Leukemia	SPEG →	-1.571	-1.030	.005	.002	3	4
OESOPHAGUS	CHST14 →	-0.934	-0.549	<.001	.004	3	4
BLOOD_Myeloma	FAM131A →	+1.920	+1.509	.006	.002	3	4
STOMACH	YPEL5 →	-2.031	-0.362	.004	<.001	3	3
PANCREAS	APAF1 →	-0.924	-0.266	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032350 vs MRPS34 — STOMACH

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